Western Mediterranean from Genoa

The capital city in the land of Leonardo, Michelangelo and the popes is today a living museum with gorgeous artwork, amazing architecture and inspiring ancient sites. At the same time, it's alive and vibrant in a 21st-century way. It's an unforgettable city to visit, and we'll warn you right now that once you've experienced it, you'll want to go back for more.

One of our favorite things to do there is walk and ogle. On a recent visit, we took one day to do the route from Vatican City and St. Peter's Basilica -- with its jaw-dropping art, statuary, and religious significance -- to Via del Corso, where our quest for the latest Italian fashions was more than fulfilled amidst the well-dressed crowd of Roman shoppers. The next day, we went on an ancient history quest past ruins and columns, traversing the same streets Julius Caesar strode (and rode) to the Colosseum, where gladiators once battled. Walking on, we were awed by the Pantheon, the well-preserved ancient symbol of Rome and now a great hangout spot.

First-time visitors, many envisioning Rome as big and congested, will be surprised by the scenic layout, with its famous seven hills and the Tiber River running through the city. (Cleopatra famously made her grand entrance from the river.) And the senses may be shocked by the general energy, hustle and bustle. With cars, taxis and scooters roaring here and there, crossing the street can be a challenge. (Don't worry; there are quiet piazzas aplenty with lovely cafes where you can get away from it all and unwind.)

The food is, of course, wonderful -- we can't eat enough pasta -- and the spirit of la dolce vita (the good life) abounds. Whenever we do such a quest in Rome, we do regular gelato stops (try the yummy pine nut flavor) or coffee breaks. And the shopping scene serves up Prada, Gucci, Armani and more. (High style can be found in more affordable brands like Furla, as well.) What could be better than that?

No question, Rome has one of the world's most important collections of once-in-a-lifetime sights to see, including St. Peter's Basilica and the Sistine Chapel, the Colosseum, the Pantheon, the Forum and on and on and on. And for those historic monuments alone, the city is worth a visit.

But if you're on an itinerary where Rome is just a port of call for the day, you won't see everything. Either resign yourself to that fact, or book a tour that will at least drive you by the main sights. Be aware the port for Rome, Civitavecchia, is about 1.5 to 2 hours from the city. (There is decent train service.) If you're beginning or ending your cruise there, plan to stay at least a couple of nights to explore the Eternal City; it's likely to steal a piece of your heart. Make sure to drop a coin in Trevi Fountain, which is said to assure you'll come back again.

Relax and enjoy the facilities and entertainment onboard your ship. If the weather is good take some sun and sunbathe on the pool deck. Otherwise explore below deck the wide range of activities that will be available during the day. Perhaps you prefer to find a quiet spot and catch up on your reading.

Marseille, gateway to Provence, is France's largest port and second largest city, with a vast history stretching back more than 2,000 years to its foundation by the Greeks in the 6th century BC. While much of the city is urban sprawl, it has a spectacular setting between dramatic limestone hills and the Mediterranean, and the once-industrial streets now feature stylish shops and cutting-edge art galleries, thanks to investment from its role as European Capital of Culture 2013. Most cruisers make a beeline for Le Vieux Port, a buzzing, picturesque harbour lined with boutiques, restaurants and cafes. This district attracts an eclectic crowd, from local fishermen to millionaires venturing ashore from James Bond-style mega-yachts. All gather to soak up Le Vieux Port's charming atmosphere, browse its bustling markets and tuck into a bowl of Marseille's classic signature dish, bouillabaisse (a rich fish stew).